Accessing and using complex multimedia documents in a digital library

Dans le cadre de trois projets européens, notre équipe a mis au point un modèle de données et un langage de requête pour bibliothèques numériques supportant l'identification, la structuration, les métadonnées, la réutilisation, et la découverte des ressources numériques. Le modèle proposé est inspiré par le Web et il est formalisé comme une théorie du premier ordre, dont certains modèles correspondent à la notion de bibliothèque numérique. En outre, une traduction complète du modèle en RDF et du langage de requêtes en SPARQL a également été proposée pour démontrer son adéquation à des applications pratiques. Le choix de RDF est dû au fait qu il est un langage de représentation généralement accepté dans le cadre des bibliothèques numériques et du Web sémantique. L objectif de cette thèse était double: concevoir et mettre en œuvre une forme simplifiée de système de gestion de bibliothèques numériques, d une part, et contribuer à l enrichissement du modèle, d autre part. Pour atteindre cet objectif nous avons développé un prototype d un système de bibliothèque numérique utilisant un stockage RDF pour faciliter la gestion interne des métadonnées. Le prototype permet aux utilisateurs de gérer et d interroger les métadonnées des ressources numériques ou non-numériques dans le système en utilisant des URIs pour identifier les ressources, un ensemble de prédicats pour la description de ressources, et des requêtes conjonctives simples pour la découverte de connaissances dans le système. Le prototype est mis en œuvre en utilisant les technologies Java et l environnement de Google Web Toolkit dont l'architecture du système se compose d'une couche de stockage, d une couche de métier logique, d une couche de service, et d une interface utilisateur. Pendant la thèse, le prototype a été construit, testé et débogué localement, puis déployé sur Google App Engine. Dans l avenir, il peut être étendu pour devenir un système complet de gestion de bibliothèques numériques. Par ailleurs, la thèse présente également notre contribution à la génération de contenu par réutilisation de ressources. Il s agit d un travail théorique dont le but est d enrichir le modèle en lui ajoutant un service important, à savoir la possibilité de création de nouvelles ressources à partir de celles stockées dans le système. L incorporation de ce service dans le système sera effectuée ultérieurement.In the context of three European projects, our research team has developed a data model and query language for digital libraries supporting identification, structuring, metadata, and discovery and reuse of digital resources. The model is inspired by the Web and it is formalized as a first-order theory, certain models of which correspond to the notion of digital library. In addition, a full translation of the model to RDF and of the query language to SPARQL has been proposed to demonstrate the feasibility of the model and its suitability for practical applications. The choice of RDF is due to the fact that it is a generally accepted representation language in the context of digital libraries and the Semantic Web. One of the major aims of the thesis was to design and actually implement a simplified form of a digital library management system based on the theoretical model. To obtain this, we have developed a prototype based on RDF and SPARQL, which uses a RDF store to facilitate internal management of metadata. The prototype allows users to manage and query metadata of digital or non-digital resources in the system, using URIs as resource identifiers, a set of predicates to model descriptions of resources, and simple conjunctive queries to discover knowledge in the system. The prototype is implemented by using Java technologies and the Google Web Toolkit framework whose system architecture consists of a storage layer, a business logic layer, a service layer and a user interface. During the thesis work, the prototype was built, tested, and debugged locally and then deployed on Google App Engine. In the future, it will be expanded to become a full fledged digital library management system. Moreover, the thesis also presents our contribution to content generation by reuse. This is mostly theoretical work whose purpose is to enrich the model and query language by providing an important community service. The incorporation of this service in the implemented system is left to future work.PARIS11-SCD-Bib. électronique (914719901) / SudocSudocFranceF

A Conceptual Design and Numerical Analysis for a Small-Scale and Low-Cost Plastic Recycling Machine

A new conceptual design for a small-scale and low-cost plastic recycling machine is generated by combining melting part and compression process. Starting with one of the outstanding requirements is in terms of an affordable-priced machine that can perform two processes with high accuracy and capacity, some issues related to balancing among quality, capacity and cost of machine occurred during a discussion. After implementing various designing methods such as Quality Function Deployment, Reverse Engineering, Morphological Matrix and Pugh Method, an idea of final concept about using an electric oven and hydraulic system to melt down and compress plastic tile which has a dimension of 300x300x9 mm was created. The design of concept is divided into two parts which are mechanical and electrical systems. In a mechanical section, the technical drawing and simulation are made to see how machine performs under operation. Besides, we examined the forces that applied in the moulds to evaluate the strength of the system. In heating and electricity section, we chose electrical components, designed oven parameters and conducted the heating simulation on the mould. In addition, the heating and cooling time was calculated based on the principles of thermodynamics and heat transfer. Furthermore, the manufacturing plan is created to estimate the essential resources producing a certain number of heat-forming machines. In general, the machine needs to be prototyped for controlling its main function and finding practical issues. After that, some improvements could be made to enhance efficiency and increase capacity by designing an optimal mould to more heat absorb and reduce post process, calculate and design more efficient oven, create faster lock mechanism and other improvements for an automatizing machine

Unexpected cases in field diagnosis of African swine fever virus in Vietnam: The needs consideration when performing molecular diagnostic tests

Background: The first confirmed case of African swine fever (ASF) in Vietnam was reported officially in February 2019. To date, ASF virus (ASFV) have been detected in 63/63 provinces in Vietnam. Currently, real-time polymerase chain reaction (PCR) is considered to be a powerful tool for viral detection in field samples, including ASFV. However, some recent reports have suggested that mismatches in primer and probe binding regions may directly affect real-time PCR qualification, leading a false-negative result.Aim: This study aims to further examine a conflicting result obtained from two OIE recommended methods, conventional PCR and real-time PCR, for ASFV detection.Methods: Two ASF suspected pigs from different provinces in the north of Vietnam were selected for this study based on clinical signs and postmortem lesions. The different results obtained by OIE-recommended conventional PCR and real-time PCR were further analyzed by the Sanger sequencing method and virus isolation in combination with hemadsorption (HAD) test using porcine alveolar macrophages cells.Results: The results showed that when the primer sequence matched perfectly with the sequences of field isolates, a mutation in probe binding region was found, indicating that a single mismatch in the probe binding site may cause a false-negative result by real-time PCR in detecting ASFV in clinical samples in Vietnam. An agreement between conventional PCR, using PPA1/PPA2 primers and two golden standard methods, virus isolation in combination with HAD assay, and sequencing method was observed in this study.Conclusion: A single mismatch in the probe binding site caused a failse-negative result by realtime PCR method in field diagnosis of ASFV. The needs consideration when selecting the appropriate molecular diagnostic methods is based on the current databases of ASFV sequences,  particularly for epidemiological surveillance of ASF. Keywords: African swine fever, PCR, Pigs, Real-time PCR, Vietna

Prevalence and risk factors for human papillomavirus infection among female sex workers in Hanoi and Ho Chi Minh City, Viet Nam: a cross-sectional study

OBJECTIVE: Female sex workers (FSWs) are at high risk of human papillomavirus (HPV) infections and cervical cancer due to their high number of sexual partners. The objectives of this study were to determine the prevalence of HPV and identify risk factors for high-risk HPV infection among FSWs in Hanoi and Ho Chi Minh City (HCMC), Viet Nam. METHODS: A cross-sectional study was conducted in Hanoi and HCMC between December 2017 and May 2018. We surveyed and screened 699 FSWs aged 318 years for HPV infection and abnormal cytology. A multivariable modified Cox regression model was used to determine risk factors for high-risk HPV infection. RESULTS: The overall prevalence of any HPV, high-risk HPV and HPV-16/18 infection in the 699 FSWs was 26.3%, 17.6% and 4.0%, respectively, and were similar in both cities. Multiple infections were identified in 127 participants (69.0%). HPV-52 was the most prevalent (7%), followed by HPV-58 (6%). Abnormal cytology was detected in 91 participants (13.0%). FSWs who are divorced (adjusted prevalence ratio [aPR]: 1.96, 95% confidence interval [CI]: 1.01-3.81), widowed (aPR: 3.26, 95% CI: 1.49-7.12) or living alone (aPR: 1.85, 95% CI: 1.01-3.39) were associated with a higher prevalence of high-risk HPV infection. DISCUSSION: Almost one in five FSWs in Viet Nam are infected with high-risk HPV. This highlights the importance of prevention strategies such as HPV vaccination and screening in this high-risk group

Brza serotipizacija virusa afričke kuge svinja zasnovana na analizi kratkih fragmenata EP402R gena koji kodira CD2-like protein

The first confirmed case of African swine fever (ASF) in Vietnam was officially reported in February 2019. To date, the ASF virus (ASFV) has been detected in all 63 cities/provinces in Vietnam. In order to get a better understanding of the potential role of the EP402R gene in a grouping of ASFV serotypes, thirty ASFV sequences of EP402R genes (accession numbers: MN711757-86) from North Central Coast of Vietnam and 68 well-known references of serotype groups from previous studies were further analyzed. Interestingly, we found that a short fragment of 90 nucleotides was very typical for 8 serological groups of ASFVs. A primer set was designed to amplicon the short fragment of 90 nucleotides using the Primer3 program to establish a simplified method for the serotyping of ASFV. Our results indicated that phylogenetic analysis of the short fragment (90 nucleotides) of the EP402R gene is a very specific and useful method for ASFV serotyping when compared to the previous method using a long fragment (816 nucleotides) of this gene and well-known serotype references based on haemadsorption inhibition (HAI) assay.Prvi potvrđen slučaj afričke kuge svinja (ASF) u Vijetnamu bio je zvanično prijavljen u februaru 2019. godine. Do danas, ASF virus (ASFV) je detektovan u 63 provincije Vijetnama. Radi boljeg razumevanja potencijalne uloge EP402R gena u grupisanju ASFV serotipova, analizirano je trideset ASFV sekvenci EP402R gena (pristupni brojevi: MN711757-86) poreklom iz Centralne severne obale Vijetnama i 68 referentnih uzoraka serotip grupa koji su dobro poznati iz prethodnih studija. Interesantan je bio nalaz da je kratak fragment od 90 nukleotida bio tipičan za 8 seroloških grupa ASF virusa. Dizajniran je set prajmera sa ciljem amplifi kacije kratkih fragmenata (90 nukleotida), korišćenjem Primer3 programa, a za uspostavljanje jednostavne metode serotipiziranja ASFV. Rezultati ukazuju da je fi logenetska analiza kratkih fragmenata (90 nukleotida) EP402R gena je veoma specifična i predstavlja korisnu metodu serotipizacije ASFV u poređenju sa prethodno opisanim metodama koje su koristile duge fragmente (816 nukleotida) ovog gena kao i dobro poznate referentne serotipove dobijene metodom inhibicije hemadsorbcije

Anal human papillomavirus prevalence and risk factors among men who have sex with men in Vietnam.

OBJECTIVES: Men who have sex with men (MSM) are at risk of human papillomavirus (HPV)-related cancers, while published data are scarce. This study determined HPV prevalence and risk factors in MSM in Vietnam to inform HPV prevention strategies in this key population. METHODS: A cross-sectional study of 799 MSM aged 16-50 years was conducted in Vietnam in 2017-2018. Information was collected on risk behaviours, and knowledge of HPV and anal cancer; rectal swabs were taken to detect anal HPV infection. An in-house polymerase chain reaction and Genoflow HPV array test kit were used for HPV detection and genotyping. RESULTS: The median age of the study participants was 25 years (range 18-52). Overall prevalence of any HPV and HPV16/18 infection was 32.3% and 11.0%, respectively. A higher prevalence of high-risk HPV infection to all 14 types tested was found in Ho Chi Minh City (30.9%) than in Hanoi (18.4%). High-risk HPV infection was associated with inconsistent condom use and history of engaging in sex under the influence of drugs (adjusted odds ratio (aOR), 2.27; 95% CI, 1.48-10.67), as well as having multiple sexual partners (aOR, 1.01; 95% CI, 1.00-1.02). CONCLUSIONS: High-risk anal HPV infections in Vietnamese MSM were significantly associated with risky sexual behaviours. A targeted HPV vaccination strategy would have substantial benefit for MSM in Vietnam

Prospects for Food Fermentation in South-East Asia, Topics From the Tropical Fermentation and Biotechnology Network at the End of the AsiFood Erasmus+Project

Fermentation has been used for centuries to produce food in South-East Asia and some foods of this region are famous in the whole world. However, in the twenty first century, issues like food safety and quality must be addressed in a world changing from local business to globalization. In Western countries, the answer to these questions has been made through hygienisation, generalization of the use of starters, specialization of agriculture and use of long-distance transportation. This may have resulted in a loss in the taste and typicity of the products, in an extensive use of antibiotics and other chemicals and eventually, in a loss in the confidence of consumers to the products. The challenges awaiting fermentation in South-East Asia are thus to improve safety and quality in a sustainable system producing tasty and typical fermented products and valorising by-products. At the end of the “AsiFood Erasmus+ project” (www.asifood.org), the goal of this paper is to present and discuss these challenges as addressed by the Tropical Fermentation Network, a group of researchers from universities, research centers and companies in Asia and Europe. This paper presents current actions and prospects on hygienic, environmental, sensorial and nutritional qualities of traditional fermented food including screening of functional bacteria and starters, food safety strategies, research for new antimicrobial compounds, development of more sustainable fermentations and valorisation of by-products. A specificity of this network is also the multidisciplinary approach dealing with microbiology, food, chemical, sensorial, and genetic analyses, biotechnology, food supply chain, consumers and ethnology

Safety and efficacy of fluoxetine on functional outcome after acute stroke (AFFINITY): a randomised, double-blind, placebo-controlled trial

Background Trials of fluoxetine for recovery after stroke report conflicting results. The Assessment oF FluoxetINe In sTroke recoverY (AFFINITY) trial aimed to show if daily oral fluoxetine for 6 months after stroke improves functional outcome in an ethnically diverse population. Methods AFFINITY was a randomised, parallel-group, double-blind, placebo-controlled trial done in 43 hospital stroke units in Australia (n=29), New Zealand (four), and Vietnam (ten). Eligible patients were adults (aged ≥18 years) with a clinical diagnosis of acute stroke in the previous 2–15 days, brain imaging consistent with ischaemic or haemorrhagic stroke, and a persisting neurological deficit that produced a modified Rankin Scale (mRS) score of 1 or more. Patients were randomly assigned 1:1 via a web-based system using a minimisation algorithm to once daily, oral fluoxetine 20 mg capsules or matching placebo for 6 months. Patients, carers, investigators, and outcome assessors were masked to the treatment allocation. The primary outcome was functional status, measured by the mRS, at 6 months. The primary analysis was an ordinal logistic regression of the mRS at 6 months, adjusted for minimisation variables. Primary and safety analyses were done according to the patient's treatment allocation. The trial is registered with the Australian New Zealand Clinical Trials Registry, ACTRN12611000774921. Findings Between Jan 11, 2013, and June 30, 2019, 1280 patients were recruited in Australia (n=532), New Zealand (n=42), and Vietnam (n=706), of whom 642 were randomly assigned to fluoxetine and 638 were randomly assigned to placebo. Mean duration of trial treatment was 167 days (SD 48·1). At 6 months, mRS data were available in 624 (97%) patients in the fluoxetine group and 632 (99%) in the placebo group. The distribution of mRS categories was similar in the fluoxetine and placebo groups (adjusted common odds ratio 0·94, 95% CI 0·76–1·15; p=0·53). Compared with patients in the placebo group, patients in the fluoxetine group had more falls (20 [3%] vs seven [1%]; p=0·018), bone fractures (19 [3%] vs six [1%]; p=0·014), and epileptic seizures (ten [2%] vs two [<1%]; p=0·038) at 6 months. Interpretation Oral fluoxetine 20 mg daily for 6 months after acute stroke did not improve functional outcome and increased the risk of falls, bone fractures, and epileptic seizures. These results do not support the use of fluoxetine to improve functional outcome after stroke

Accès et utilisation de documents multimédia complexes dans une bibliothèque numérique

In the context of three European projects, our research team has developed a data model and query language for digital libraries supporting identification, structuring, metadata, and discovery and reuse of digital resources. The model is inspired by the Web and it is formalized as a first-order theory, certain models of which correspond to the notion of digital library. In addition, a full translation of the model to RDF and of the query language to SPARQL has been proposed to demonstrate the feasibility of the model and its suitability for practical applications. The choice of RDF is due to the fact that it is a generally accepted representation language in the context of digital libraries and the Semantic Web. One of the major aims of the thesis was to design and actually implement a simplified form of a digital library management system based on the theoretical model. To obtain this, we have developed a prototype based on RDF and SPARQL, which uses a RDF store to facilitate internal management of metadata. The prototype allows users to manage and query metadata of digital or non-digital resources in the system, using URIs as resource identifiers, a set of predicates to model descriptions of resources, and simple conjunctive queries to discover knowledge in the system. The prototype is implemented by using Java technologies and the Google Web Toolkit framework whose system architecture consists of a storage layer, a business logic layer, a service layer and a user interface. During the thesis work, the prototype was built, tested, and debugged locally and then deployed on Google App Engine. In the future, it will be expanded to become a full fledged digital library management system. Moreover, the thesis also presents our contribution to content generation by reuse. This is mostly theoretical work whose purpose is to enrich the model and query language by providing an important community service. The incorporation of this service in the implemented system is left to future work.Dans le cadre de trois projets européens, notre équipe a mis au point un modèle de données et un langage de requête pour bibliothèques numériques supportant l'identification, la structuration, les métadonnées, la réutilisation, et la découverte des ressources numériques. Le modèle proposé est inspiré par le Web et il est formalisé comme une théorie du premier ordre, dont certains modèles correspondent à la notion de bibliothèque numérique. En outre, une traduction complète du modèle en RDF et du langage de requêtes en SPARQL a également été proposée pour démontrer son adéquation à des applications pratiques. Le choix de RDF est dû au fait qu’il est un langage de représentation généralement accepté dans le cadre des bibliothèques numériques et du Web sémantique. L’objectif de cette thèse était double: concevoir et mettre en œuvre une forme simplifiée de système de gestion de bibliothèques numériques, d’une part, et contribuer à l’enrichissement du modèle, d’autre part. Pour atteindre cet objectif nous avons développé un prototype d’un système de bibliothèque numérique utilisant un stockage RDF pour faciliter la gestion interne des métadonnées. Le prototype permet aux utilisateurs de gérer et d’interroger les métadonnées des ressources numériques ou non-numériques dans le système en utilisant des URIs pour identifier les ressources, un ensemble de prédicats pour la description de ressources, et des requêtes conjonctives simples pour la découverte de connaissances dans le système. Le prototype est mis en œuvre en utilisant les technologies Java et l’environnement de Google Web Toolkit dont l'architecture du système se compose d'une couche de stockage, d’une couche de métier logique, d’une couche de service, et d’une interface utilisateur. Pendant la thèse, le prototype a été construit, testé et débogué localement, puis déployé sur Google App Engine. Dans l’avenir, il peut être étendu pour devenir un système complet de gestion de bibliothèques numériques. Par ailleurs, la thèse présente également notre contribution à la génération de contenu par réutilisation de ressources. Il s’agit d’un travail théorique dont le but est d’enrichir le modèle en lui ajoutant un service important, à savoir la possibilité de création de nouvelles ressources à partir de celles stockées dans le système. L’incorporation de ce service dans le système sera effectuée ultérieurement